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Related post: September 30, 1990
TITLE Pepcid 40 Mg OF PROJECT (80 characters or less. Title must fit on one line
Retroviral Transfer of p47-phox Into
between the borders.)
Murine Cells and Human Myeloid Cell Lines
PRINCIPAL INVESTIGATOR (List other professional personnel below
PI: Karen J. Lomax, M.D.
Others: Charles S. Cobbs
Scott M. Freeman, M.D.
R. Pepcid 20 Mg Michael Blaese, M.D.
Thomas L. Leto, Ph.D.
Harry L. Malech, M.D.
John Pepcid Cost I. Gallin, M.D.
the Principal Investigator.) Pepcid Tablets (Name, title, laboratory, and institute affiliation)
Head, Gene Therapy Unit /LCI /NIAID
Pre-URTA Fellow/LCI /NIAID
Fellow, Div. of Cancer Biology and Diag/NCI
Division of Cancer Biology and Diagnosis/NC::
Senior Staff Fellow/ LCI/NIAID
Head, BDS/LCI/NIAID
Director/DIR/NIAID
COOPERATING UNITS (if any)
Cellular Immunology Section/ Division Cost Of Pepcid of Cancer Biology and Diagnosis/NCI
Bacterial Diseases Section/LCI/NIAID
LAB/BRANCH
T.ahnrat-ory of Clinical Investigation
SECTION
r.pnp Thprapy Unit
INSTITUTE AND LOCATION
NIAID, NTH, Rpfhpsda, Otc Pepcid MP 20892
TOTAL MAN-YEARS:
1.5
PROFESSIONAL:
1.5
CHECK APPROPRIATE BOX(ES)
LU (a) Human subjects
□ (a1) Minors
□ (a2) Interviews
(b) Human tissues Buy Pepcid □ Pepcid Liquid (c) Neither
SUMMARY OF Pepcid 20 WORK (Use standard unreduced type. Do not exceed the space provided.)
The purpose of this non-clinical, IIDEA project is to study the feasibility of
using retroviral vectors to transfer the gene which is abnormal in autosomal
recessive Chronic Granulomatous Disease (p47-phox) into human hematopoietic cells
Development of retrovirus producer cell lines capable of infecting human blood
cells will provide the opportunity to study expression of this protein in precur-
sor and differentiated hematopoietic cells. A cDNA for p47-phox containing the
protein coding- sequence has been cloned into a retroviral vector known as pLXSN.
Two murine producer cell lines have been established, one producing an ecotropic
retrovirus capable of infecting rodent cells and the other producing amphotropic
retrovirus capable of infecting Pepcid Ac a wide range of mammalian and avian cells. The
amphotropic virus containing p47-phox in both normal (sense) and reverse (anti-
sense) orientations was used to infect two leukemia cell lines, HL-60 and U937.
RNA and protein analysis demonstrated retrovirally transferred p47-phox genes in
these Pepcid Iv cells. In addition, Epstein Barr Virus transformed B lymphocytes from a
normal individual and an AR-CGD patient were also infected. These lines also
appear to have been transduced by the retroviruses based on protein and RNA
analysis. Assays to determine whether the protein made from the transferred gene
is functional are still in progress. EBV transformed B lymphocyte cell lines
derived from AR-CGD patient cells may be helpful in studies of correction of the
defect since these cells in normals produce a Pepcid Coupon small amount of superoxide and can
be studied at the Buy Pepcid Online functional as well as molecular level. Expression of transferred
p47-phox in murine What Is Pepcid bone marrow and hematopoietic reconstitution of an irradiated
mouse will be necessary before primate and human studies can proceed. Preliminary
experiments indicate that Pepcid Otc it is possible to transfer Pepcid Coupons this gene into murine bone
marrow.
6-41
PHS 6040 (Rev. 1/84)
GPO 914-91$
PROJECT NUMBER
DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE
NOTICE OF INTRAMURAL RESEARCH PROJECT zOl AI 00593-01
PERIOO COVERED
October 1, 1989 - September 30, 1990
TITLE OF PROJECT /SO characters or iess T >ne rnust '<' on one line Perween the Borders I
Mediator Release Resulting from Induced Hereditary Angioedema Swelling
PRINCIPAL INVESTIGATOR lUst other professional personnel Mow the Principal investigator ) (Name title, laboratory, ana institute affiliation)
PI: Arthur Thomas Waytes, M.D., Medical Staff Fellow, LCI, NIAID
Other: Michael M. Frank, Pepcid 20mg M.D., Chief, LCI, NIAID
COOPERATING UNITS iff any)
LAB/BRANCH
Laboratory of Clinical Investigation
SECTION
Clinical Immunology Section
INSTITUTE AND LOCATION
NIAID, NIH, Bethesda, Maryland 20892
TOTAL MAN-YEARS j PROFESSIONAL.
1 i 1
CHECK APPROPRIATE BOX(ES)
E (a) Human subjects C (b) Human tissues i_J (c) Neither
C (al) Minors
□ (a2) Liquid Pepcid Interviews
SUMMARY OF WORK (Use standard Pepcid Price unreduced ype Do not exceed the space provided )
Hereditary Angioedema (HAE) is characterized by recurrent episodes of
edema, believed to result from a marked decrease in functional CI inhibitor (CI
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